Ranolazine can markedly increase tacrolimus blood levels
نویسندگان
چکیده
We report the case of a renal transplant patient on tacrolimus who developed a fully reversible renal failure and a doubling in serum tacrolimus closely associated with initiation of ranolazine (Ranexa) treatment, a new anti-angina drug recently introduced in Europe.
منابع مشابه
Drug Interaction between Sirolimus and Ranolazine in a Kidney Transplant Patient
Purpose. The case of a kidney transplant recipient who experienced a probable drug interaction between sirolimus and ranolazine is reported. Summary. The narrow therapeutic window of immunosuppressive therapy in transplant recipients requires close monitoring for potential drug-drug interactions. The patient, a 57-year-old Caucasian male kidney transplant recipient, was stable for years on siro...
متن کاملRanolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion.
We tested the effect of the antianginal agent ranolazine on ventricular arrhythmias in an ischemic model using two protocols. In protocol 1, anesthetized rats received either vehicle or ranolazine (10 mg/kg, iv bolus) and were subjected to 5 min of left coronary artery (LCA) occlusion and 5 min of reperfusion with electrocardiogram and blood pressure monitoring. In protocol 2, rats received eit...
متن کاملRanolazine Attenuates Trastuzumab-Induced Heart Dysfunction by Modulating ROS Production
The ErbB2 blocker trastuzumab improves survival in oncologic patients, but can cause cardiotoxicity. The late Na+ current inhibitor ranolazine has been shown to counter experimental HF, including doxorubicin cardiotoxicity (a condition characterized by derangements in redox balance), by lowering the levels of reactive oxygen species (ROS). Since ErbB2 can modulate ROS signaling, we tested wheth...
متن کاملRanolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity.
RATIONALE Previously, we demonstrated that a deoxycorticosterone acetate (DOCA)-salt hypertensive mouse model produces cardiac oxidative stress and diastolic dysfunction with preserved systolic function. Oxidative stress has been shown to increase late inward sodium current (I(Na)), reducing the net cytosolic Ca(2+) efflux. OBJECTIVE Oxidative stress in the DOCA-salt model may increase late I...
متن کاملRanolazine and the myocardial demand-supply balance.
Early studies of ranolazine centered on reductions in myocardial oxygen demand produced by partial inhibition of fatty acid oxidation, particularly as free fatty acid levels increase locally during ischemic episodes. More recent studies report that this mechanism is unlikely to be operative at the plasma levels of ranolazine associated with beneficial clinical effect. A reduction in myocardial ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2011